https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24092 Wed 24 Nov 2021 15:51:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36989 Wed 10 Nov 2021 15:12:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30964 100) epialleles. RNA-polymerase-II (Pol-II) bound only to three particular epialleles in cAMP-stimulated cells, while phospho-cAMP response element-binding protein (pCREB) bound to only one epiallele, which was different from those selected by Pol-II. Binding of TATA-binding protein increased during syncytial differentiation preferentially at epialleles compatible with Pol-II and pCREB binding. Histone-3 acetylation was detected only at epialleles targeted by Pol-II and pCREB, while gene activating histone-4 acetylation and histone-3-lysine-4 trimethylation occurred at CRH epialleles not associated with Pol-II or pCREB. The suppressive histone-3-lysine-27 trimethyl and-lysine-9 trimethyl modifications showed little or no epiallele preference. The epiallele selectivity of activating histone modifications and transcription factor binding demonstrates the epigenetic and functional diversity of the CRH gene in trophoblasts, which is controlled predominantly by the patterns, not the overall extent, of promoter methylation. We propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies.]]> Tue 24 Apr 2018 15:36:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22723 Tue 24 Apr 2018 15:33:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40524 Thu 14 Jul 2022 09:26:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13298 Sat 24 Mar 2018 08:18:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19071 Sat 24 Mar 2018 08:05:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54926 Fri 22 Mar 2024 14:33:40 AEDT ]]>